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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
34.55
Human Site:
T600
Identified Species:
54.29
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
T600
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
T600
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
T600
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Dog
Lupus familis
XP_538730
651
74149
T600
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
T592
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Rat
Rattus norvegicus
P54645
559
63955
S524
S
E
V
S
L
T
S
S
V
T
S
L
D
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
T604
G
Y
T
L
K
C
Q
T
Q
S
D
F
G
K
V
Chicken
Gallus gallus
NP_001026680
657
74208
T606
G
Y
T
L
K
C
Q
T
K
P
D
F
G
R
E
Frog
Xenopus laevis
NP_001081569
651
74289
T600
G
Y
T
L
K
C
K
T
Q
S
D
F
G
K
V
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
N857
E
S
V
M
G
S
Y
N
P
Y
L
Q
G
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
K571
G
I
R
R
K
R
L
K
G
N
A
W
V
Y
K
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
Q653
G
W
K
F
L
A
T
Q
E
T
V
H
G
W
M
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
K920
G
Y
T
L
R
C
K
K
Q
D
S
K
G
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
S405
S
L
H
M
V
Q
V
S
K
S
K
G
D
T
L
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
S592
K
F
D
G
W
E
S
S
Y
G
D
D
T
T
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
100
73.3
93.3
6.6
N.A.
N.A.
13.3
13.3
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
86.6
100
13.3
N.A.
N.A.
26.6
40
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
0
7
0
0
7
0
% A
% Cys:
0
0
0
0
0
60
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
0
7
60
7
14
0
0
% D
% Glu:
7
7
0
0
0
7
0
0
7
0
0
0
0
0
7
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
0
54
0
0
0
% F
% Gly:
74
0
0
7
7
0
0
0
7
7
0
7
74
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
7
0
60
0
14
14
14
0
7
7
0
54
7
% K
% Leu:
0
7
0
60
14
0
7
0
0
0
7
7
0
0
7
% L
% Met:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
7
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
47
7
54
0
0
7
0
0
0
% Q
% Arg:
0
0
7
7
7
7
0
0
0
0
0
0
0
7
0
% R
% Ser:
14
7
0
7
0
7
14
20
0
54
14
0
0
7
14
% S
% Thr:
0
0
60
0
0
7
7
54
0
14
0
0
7
14
7
% T
% Val:
0
0
14
0
7
0
7
0
7
0
7
0
7
0
54
% V
% Trp:
0
7
0
0
7
0
0
0
0
0
0
7
0
7
0
% W
% Tyr:
0
60
0
0
0
0
7
0
7
7
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _